RUBCNL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	25 studies	27% ± 10%	Explore
naive B cell	16 studies	30% ± 10%	Explore
memory B cell	15 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	12 studies	31% ± 9%	Explore
microglial cell	8 studies	40% ± 14%	Explore
macrophage	7 studies	29% ± 10%	Explore
precursor B cell	5 studies	57% ± 14%	Explore
immature B cell	5 studies	45% ± 8%	Explore
astrocyte	5 studies	24% ± 9%	Explore
pro-B cell	3 studies	26% ± 7%	Explore
GABAergic neuron	3 studies	23% ± 2%	Explore
glutamatergic neuron	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	88%	1098.85	854 / 966	80%	16.83	422 / 527
brain	91%	340.43	2410 / 2642	68%	2.68	478 / 705
thymus	83%	322.48	542 / 653	75%	2.80	451 / 605
skin	70%	326.05	1269 / 1809	78%	4.00	367 / 472
lung	99%	836.90	574 / 578	41%	0.87	468 / 1155
breast	79%	320.66	363 / 459	55%	1.30	615 / 1118
spleen	100%	3487.56	241 / 241	0%	0	0 / 0
peripheral blood	99%	3024.90	922 / 929	0%	0	0 / 0
bladder	57%	210.10	12 / 21	37%	5.32	185 / 504
uterus	65%	251.70	111 / 170	28%	0.83	129 / 459
lymph node	0%	0	0 / 0	93%	26.60	27 / 29
stomach	30%	76.41	107 / 359	63%	13.31	181 / 286
prostate	77%	297.65	189 / 245	14%	0.23	72 / 502
adipose	87%	394.72	1044 / 1204	0%	0	0 / 0
adrenal gland	66%	172.45	169 / 258	3%	0.06	7 / 230
kidney	37%	116.54	33 / 89	28%	0.50	254 / 901
esophagus	37%	84.93	540 / 1445	26%	0.49	47 / 183
blood vessel	62%	257.30	822 / 1335	0%	0	0 / 0
pancreas	14%	34.07	47 / 328	43%	1.06	76 / 178
tonsil	0%	0	0 / 0	51%	1.28	23 / 45
ovary	13%	26.94	24 / 180	26%	0.46	112 / 430
liver	24%	65.14	55 / 226	7%	0.19	29 / 406
heart	18%	43.54	156 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	8%	0.12	6 / 80
muscle	2%	4.89	19 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0070873	Biological process	regulation of glycogen metabolic process
GO_0061910	Biological process	autophagosome-endosome fusion
GO_0019216	Biological process	regulation of lipid metabolic process
GO_0097352	Biological process	autophagosome maturation
GO_0006629	Biological process	lipid metabolic process
GO_0061909	Biological process	autophagosome-lysosome fusion
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0000421	Cellular component	autophagosome membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0070273	Molecular function	phosphatidylinositol-4-phosphate binding
GO_1901981	Molecular function	phosphatidylinositol phosphate binding
GO_0005515	Molecular function	protein binding
GO_0010314	Molecular function	phosphatidylinositol-5-phosphate binding
GO_0032266	Molecular function	phosphatidylinositol-3-phosphate binding

IV. Literature review

[source]

Gene name	RUBCNL
Protein name	Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) Rubicon like autophagy enhancer Protein-associated with UVRAG as autophagy enhancer
Synonyms	KIAA0226L C13orf18
Description	FUNCTION: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy . Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex . Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes . Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) . In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). .
Accessions	ENST00000378797.6 E7EMA2 ENST00000417405 B7ZBN5 ENST00000676051.1 [Q9H714-6] ENST00000429979.6 [Q9H714-5] ENST00000676063.1 ENST00000439642.1 ENST00000389908.7 [Q9H714-5] ENST00000441284.6 ENST00000378781.7 ENST00000676084.1 ENST00000676114.1 [Q9H714-5] ENST00000378784.8 [Q9H714-3] Q9H714 A0A6Q8PGJ9 ENST00000675992.1 A0A6Q8PFX0 A8XR14 ENST00000676307.1 [Q9H714-5] Q5W050 ENST00000378787.7 [Q9H714-4] A0A0A0MRV7 ENST00000631139.2 [Q9H714-6] A0A6Q8PF39 ENST00000675291.1 A0A6Q8PH05 ENST00000409879.6 ENST00000417405.2 [Q9H714-4] ENST00000675585.1

RUBCNL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review