RTN4RL1 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	36% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	99%	1201.53	453 / 459	91%	29.41	1017 / 1118
prostate	94%	627.83	231 / 245	91%	13.38	456 / 502
adrenal gland	97%	525.12	249 / 258	27%	2.50	63 / 230
brain	86%	821.76	2276 / 2642	36%	5.09	256 / 705
skin	75%	1053.73	1350 / 1809	47%	10.17	223 / 472
pancreas	67%	156.06	220 / 328	51%	4.67	91 / 178
liver	62%	211.15	140 / 226	53%	6.76	216 / 406
lung	64%	196.60	370 / 578	40%	3.66	464 / 1155
thymus	83%	262.74	540 / 653	20%	2.01	124 / 605
uterus	62%	171.96	105 / 170	36%	4.47	167 / 459
kidney	60%	162.16	53 / 89	36%	3.53	321 / 901
eye	0%	0	0 / 0	93%	36.83	74 / 80
adipose	92%	651.45	1112 / 1204	0%	0	0 / 0
bladder	62%	253.57	13 / 21	24%	2.34	120 / 504
esophagus	40%	91.95	574 / 1445	35%	4.97	64 / 183
heart	69%	225.96	595 / 861	0%	0	0 / 0
spleen	66%	175.55	160 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	14.53	29 / 45
ovary	40%	115.37	72 / 180	24%	2.49	102 / 430
blood vessel	58%	246.63	768 / 1335	0%	0	0 / 0
muscle	43%	137.46	344 / 803	0%	0	0 / 0
stomach	26%	50.96	93 / 359	15%	1.23	44 / 286
intestine	10%	24.66	98 / 966	18%	1.46	94 / 527
peripheral blood	0%	0.16	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0031103	Biological process	axon regeneration
GO_0048681	Biological process	negative regulation of axon regeneration
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0022038	Biological process	corpus callosum development
GO_0042995	Cellular component	cell projection
GO_0043204	Cellular component	perikaryon
GO_0045121	Cellular component	membrane raft
GO_0005615	Cellular component	extracellular space
GO_0009986	Cellular component	cell surface
GO_0098552	Cellular component	side of membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031012	Cellular component	extracellular matrix
GO_0008201	Molecular function	heparin binding
GO_0035374	Molecular function	chondroitin sulfate binding
GO_0038023	Molecular function	signaling receptor activity
GO_0005515	Molecular function	protein binding

Gene name	RTN4RL1
Protein name	Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
Synonyms	NGRL2 NGRH2
Description	FUNCTION: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton . .
Accessions	Q86UN2 ENST00000331238.7

RTN4RL1 report