Insufficient scRNA-seq data for expression of RSPO4 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 98% | 402.10 | 643 / 653 | 72% | 18.69 | 437 / 605 |
| lung | 100% | 1493.82 | 577 / 578 | 30% | 2.84 | 352 / 1155 |
| brain | 86% | 366.14 | 2277 / 2642 | 31% | 1.06 | 219 / 705 |
| skin | 88% | 245.40 | 1583 / 1809 | 21% | 5.36 | 98 / 472 |
| ovary | 27% | 35.90 | 48 / 180 | 74% | 13.19 | 320 / 430 |
| esophagus | 72% | 181.06 | 1045 / 1445 | 25% | 3.06 | 45 / 183 |
| breast | 60% | 160.68 | 276 / 459 | 15% | 1.31 | 165 / 1118 |
| adrenal gland | 11% | 11.08 | 29 / 258 | 52% | 15.89 | 119 / 230 |
| bladder | 24% | 16.76 | 5 / 21 | 31% | 3.53 | 158 / 504 |
| kidney | 43% | 48.22 | 38 / 89 | 7% | 0.63 | 63 / 901 |
| prostate | 42% | 47.09 | 103 / 245 | 1% | 0.03 | 4 / 502 |
| uterus | 17% | 25.61 | 29 / 170 | 24% | 3.95 | 110 / 459 |
| blood vessel | 34% | 62.15 | 457 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 18% | 16.58 | 178 / 966 | 9% | 0.78 | 45 / 527 |
| stomach | 10% | 8.51 | 35 / 359 | 12% | 1.71 | 35 / 286 |
| eye | 0% | 0 | 0 / 0 | 19% | 1.81 | 15 / 80 |
| spleen | 18% | 14.46 | 43 / 241 | 0% | 0 | 0 / 0 |
| heart | 17% | 20.73 | 147 / 861 | 0% | 0 | 0 / 0 |
| adipose | 16% | 16.58 | 196 / 1204 | 0% | 0 | 0 / 0 |
| liver | 11% | 9.20 | 25 / 226 | 4% | 0.27 | 15 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.79 | 5 / 45 |
| pancreas | 5% | 4.23 | 18 / 328 | 6% | 1.19 | 10 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.10 | 1 / 29 |
| muscle | 0% | 0.28 | 3 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.13 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
| GO_0035878 | Biological process | nail development |
| GO_0005576 | Cellular component | extracellular region |
| GO_0008201 | Molecular function | heparin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RSPO4 |
| Protein name | R-spondin-4 (Roof plate-specific spondin-4) (hRspo4) |
| Synonyms | C20orf182 |
| Description | FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway . . |
| Accessions | ENST00000400634.2 [Q2I0M5-2] ENST00000217260.9 [Q2I0M5-1] Q2I0M5 |
