Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasmablast | 6 studies | 52% ± 23% | |
| T cell | 6 studies | 41% ± 15% | |
| transit amplifying cell | 5 studies | 38% ± 12% | |
| CD8-positive, alpha-beta T cell | 5 studies | 52% ± 14% | |
| B cell | 4 studies | 29% ± 11% | |
| plasma cell | 4 studies | 33% ± 11% | |
| natural killer cell | 4 studies | 40% ± 12% | |
| CD4-positive, alpha-beta T cell | 4 studies | 68% ± 7% | |
| erythroblast | 3 studies | 45% ± 21% | |
| hematopoietic precursor cell | 3 studies | 21% ± 5% | |
| erythrocyte | 3 studies | 38% ± 15% | |
| pro-B cell | 3 studies | 32% ± 7% | |
| effector CD8-positive, alpha-beta T cell | 3 studies | 47% ± 14% |
Insufficient scRNA-seq data for expression of RRM2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 75% | 2729.55 | 1363 / 1809 | 91% | 24.00 | 430 / 472 |
| lung | 70% | 469.91 | 405 / 578 | 90% | 29.82 | 1040 / 1155 |
| intestine | 55% | 727.23 | 530 / 966 | 98% | 42.01 | 516 / 527 |
| stomach | 50% | 621.80 | 180 / 359 | 99% | 37.99 | 283 / 286 |
| esophagus | 44% | 1129.59 | 643 / 1445 | 99% | 41.57 | 182 / 183 |
| bladder | 33% | 96.62 | 7 / 21 | 94% | 37.16 | 472 / 504 |
| uterus | 8% | 40.75 | 14 / 170 | 98% | 54.34 | 449 / 459 |
| breast | 18% | 64.86 | 84 / 459 | 86% | 23.20 | 966 / 1118 |
| ovary | 9% | 54.87 | 17 / 180 | 91% | 18.04 | 393 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 52.76 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 62.97 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.30 | 1 / 1 |
| spleen | 98% | 1951.69 | 237 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 16% | 46.77 | 51 / 328 | 74% | 11.68 | 132 / 178 |
| liver | 31% | 320.71 | 71 / 226 | 57% | 9.20 | 233 / 406 |
| peripheral blood | 81% | 4658.41 | 755 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 50% | 221.54 | 128 / 258 | 13% | 3.00 | 31 / 230 |
| kidney | 27% | 172.17 | 24 / 89 | 18% | 2.52 | 161 / 901 |
| brain | 1% | 6.33 | 37 / 2642 | 40% | 9.10 | 281 / 705 |
| prostate | 18% | 58.80 | 44 / 245 | 17% | 2.01 | 86 / 502 |
| thymus | 14% | 51.14 | 94 / 653 | 16% | 7.51 | 99 / 605 |
| adipose | 28% | 123.05 | 340 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 16% | 49.04 | 220 / 1335 | 0% | 0 | 0 / 0 |
| heart | 11% | 37.30 | 93 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.51 | 5 / 80 |
| muscle | 1% | 2.42 | 11 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1900087 | Biological process | positive regulation of G1/S transition of mitotic cell cycle |
| GO_0051290 | Biological process | protein heterotetramerization |
| GO_0009185 | Biological process | ribonucleoside diphosphate metabolic process |
| GO_0001824 | Biological process | blastocyst development |
| GO_0009263 | Biological process | deoxyribonucleotide biosynthetic process |
| GO_0009265 | Biological process | 2'-deoxyribonucleotide biosynthetic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0005971 | Cellular component | ribonucleoside-diphosphate reductase complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0004748 | Molecular function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008199 | Molecular function | ferric iron binding |
| Gene name | RRM2 |
| Protein name | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) Ribonucleotide reductase regulatory subunit M2 |
| Synonyms | RR2 |
| Description | FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| Accessions | ENST00000646978.1 ENST00000641198.1 [P31350-1] A0A7P0SBL1 ENST00000304567.10 [P31350-1] P31350 A0A2R8Y837 A0A286YFD6 ENST00000641498.1 ENST00000360566.6 [P31350-2] ENST00000615152.5 |