RRAD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005246Molecular functioncalcium channel regulator activity
GO_0005525Molecular functionGTP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRRAD
Protein nameGTP-binding protein RAD (RAD1) (Ras associated with diabetes)
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
SynonymsRAD
DescriptionFUNCTION: May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway . Inhibits phosphorylation and activation of CAMK2D . .

AccessionsENST00000299759.11
P55042
J3KRG9
ENST00000568915.5
ENST00000566577.1
J3KSM6