RPUSD4 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	27% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RPUSD4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	1724.19	328 / 328	100%	17.76	178 / 178
prostate	100%	1401.47	245 / 245	100%	21.30	502 / 502
stomach	100%	1721.42	359 / 359	100%	22.76	286 / 286
esophagus	100%	1260.86	1444 / 1445	100%	16.64	183 / 183
intestine	100%	1391.86	966 / 966	100%	26.60	526 / 527
bladder	100%	1422.38	21 / 21	100%	21.05	503 / 504
lung	100%	1145.57	576 / 578	100%	19.01	1155 / 1155
breast	100%	1663.28	459 / 459	100%	18.45	1114 / 1118
liver	100%	1234.46	226 / 226	100%	13.61	404 / 406
skin	100%	1884.44	1809 / 1809	99%	20.17	469 / 472
thymus	100%	1271.13	652 / 653	100%	17.55	602 / 605
uterus	100%	1680.29	170 / 170	99%	17.63	456 / 459
ovary	100%	1992.22	180 / 180	99%	14.40	426 / 430
kidney	100%	1228.96	89 / 89	99%	16.32	890 / 901
brain	99%	973.26	2607 / 2642	100%	22.61	705 / 705
adrenal gland	100%	1369.90	258 / 258	93%	11.21	213 / 230
adipose	100%	1686.47	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	28.97	80 / 80
lymph node	0%	0	0 / 0	100%	29.90	29 / 29
muscle	100%	7149.79	803 / 803	0%	0	0 / 0
spleen	100%	1667.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	14.31	45 / 45
ureter	0%	0	0 / 0	100%	8.68	1 / 1
blood vessel	100%	1177.93	1334 / 1335	0%	0	0 / 0
heart	98%	1525.59	842 / 861	0%	0	0 / 0
peripheral blood	85%	903.95	788 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1990481	Biological process	mRNA pseudouridine synthesis
GO_0070131	Biological process	positive regulation of mitochondrial translation
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0006364	Biological process	rRNA processing
GO_0070902	Biological process	mitochondrial tRNA pseudouridine synthesis
GO_0035770	Cellular component	ribonucleoprotein granule
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_0009982	Molecular function	pseudouridine synthase activity
GO_0000049	Molecular function	tRNA binding
GO_1990400	Molecular function	mitochondrial ribosomal large subunit rRNA binding
GO_0106029	Molecular function	tRNA pseudouridine synthase activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	RPUSD4
Protein name	Pseudouridylate synthase RPUSD4, mitochondrial (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) Pseudouridylate synthase RPUSD4, mitochondrial (RNA pseudouridylate synthase domain-containing protein 4)
Synonyms
Description	FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates . Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) . This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Acts on position 39 in mitochondrial tRNA(Phe) . Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing . .
Accessions	ENST00000533628.5 [Q96CM3-2] E9PJV3 ENST00000532674.2 Q96CM3 ENST00000298317.9 [Q96CM3-1]

RPUSD4 report