RPRD1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0031124Biological processmRNA 3'-end processing
GO_0001111Biological processRNA polymerase II promoter clearance
GO_0010564Biological processregulation of cell cycle process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097550Cellular componenttranscription preinitiation complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0099122Molecular functionRNA polymerase II C-terminal domain binding

IV. Literature review

[source]
Gene nameRPRD1B
Protein nameRegulation of nuclear pre-mRNA domain-containing protein
Regulation of nuclear pre-mRNA domain containing 1B
Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)
SynonymsC20orf77
CREPT
DescriptionFUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. .

FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. .

FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. .

AccessionsENST00000614670.1
ENST00000622494.1
A0A087WUK3
Q9NQG5
ENST00000449186.2
ENST00000373433.9
ENST00000495457.1
E9PQF3
A0A087X2D2
ENST00000462548.6
A2A2M0
E9PIQ9