ROBO3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ROBO3 at tissue level.

III. Associated gene sets

GO_0016199Biological processaxon midline choice point recognition
GO_1902669Biological processpositive regulation of axon guidance
GO_0006935Biological processchemotaxis
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0070593Biological processdendrite self-avoidance
GO_0007411Biological processaxon guidance
GO_0030424Cellular componentaxon
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0098632Molecular functioncell-cell adhesion mediator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameROBO3
Protein nameROBO3 protein
Roundabout homolog 3 (Roundabout-like protein 3)
Roundabout guidance receptor 3
Synonyms
DescriptionFUNCTION: Receptor involved in axon guidance during development . Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (By similarity). .

AccessionsF5H0K7
ENST00000543966.5
Q96HH0
ENST00000397801.6 [Q96MS0-1]
ENST00000538940.5
F5GWJ5
Q96MS0