RNF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0048675Biological processaxon extension
GO_0030517Biological processnegative regulation of axon extension
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF6
Protein nameE3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27)
Ring finger protein 6 isoform 2
Ring finger protein 6 isoform 1
SynonymsSPG2
DescriptionFUNCTION: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity . May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity). .

AccessionsENST00000381588.9 [Q9Y252-1]
A0A024RDP2
A0A0S2Z4G9
ENST00000346166.7 [Q9Y252-1]
ENST00000381570.7 [Q9Y252-1]
Q9Y252