RNF43 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF43 at tissue level.

III. Associated gene sets

GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016055Biological processWnt signaling pathway
GO_0038018Biological processWnt receptor catabolic process
GO_0072089Biological processstem cell proliferation
GO_0005635Cellular componentnuclear envelope
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005109Molecular functionfrizzled binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF43
Protein nameE3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway . Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). .

AccessionsENST00000584437.5 [Q68DV7-1]
Q68DV7
ENST00000581868.1
ENST00000407977.7 [Q68DV7-1]
ENST00000577716.5 [Q68DV7-1]
ENST00000583753.5 [Q68DV7-2]
J3KSE3
ENST00000577625.5 [Q68DV7-3]