RNF26 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF26 at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0050687Biological processnegative regulation of defense response to virus
GO_0032479Biological processregulation of type I interferon production
GO_0007032Biological processendosome organization
GO_1905719Biological processprotein localization to perinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameRNF26
Protein nameE3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud . Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 . Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport . Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING . Also required to limit type I interferon response by promoting autophagic degradation of IRF3 . .

AccessionsENST00000311413.5
Q9BY78