RNF20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007346Biological processregulation of mitotic cell cycle
GO_0006355Biological processregulation of DNA-templated transcription
GO_0030336Biological processnegative regulation of cell migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0033503Cellular componentHULC complex
GO_0005730Cellular componentnucleolus
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0002039Molecular functionp53 binding
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0140850Molecular functionhistone H2B C-terminal K residue ubiquitin ligase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF20
Protein nameE3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
E3 ubiquitin protein ligase (EC 2.3.2.27)
SynonymsBRE1A
DescriptionFUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. .; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. .

AccessionsENST00000374819.6
ENST00000466817.1
ENST00000389120.8
C9JWJ4
C9J0A5
C9JXC9
Q5VTR2
Q05DC0
A0PJJ6
ENST00000479306.5