RNF112 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF112 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0007029Biological processendoplasmic reticulum organization
GO_0051865Biological processprotein autoubiquitination
GO_0033194Biological processresponse to hydroperoxide
GO_0030182Biological processneuron differentiation
GO_0045687Biological processpositive regulation of glial cell differentiation
GO_0070315Biological processG1 to G0 transition involved in cell differentiation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0051726Biological processregulation of cell cycle
GO_1990403Biological processembryonic brain development
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0016604Cellular componentnuclear body
GO_0008021Cellular componentsynaptic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0044297Cellular componentcell body
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005525Molecular functionGTP binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRNF112
Protein nameRING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179)
Ring finger protein 112
SynonymsZNF179
BFP
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins . Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity). .

AccessionsENST00000461366.2 [Q9ULX5-1]
ENST00000575165.6
J3QRB8
Q9ULX5