RNASEL report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNASEL at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNASEL at tissue level.

III. Associated gene sets

GO_0045071Biological processnegative regulation of viral genome replication
GO_0046326Biological processpositive regulation of glucose import
GO_0006397Biological processmRNA processing
GO_0043488Biological processregulation of mRNA stability
GO_0006396Biological processRNA processing
GO_0051607Biological processdefense response to virus
GO_0006468Biological processprotein phosphorylation
GO_0006364Biological processrRNA processing
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005575Cellular componentcellular_component
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0004521Molecular functionRNA endonuclease activity
GO_0019843Molecular functionrRNA binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity

IV. Literature review

[source]
Gene nameRNASEL
Protein nameRibonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L)
SynonymsRNS4
DescriptionFUNCTION: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis . Might play a central role in the regulation of mRNA turnover . Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. .

AccessionsQ1RLL8
Q05823
ENST00000539397.1 [Q05823-2]
ENST00000367559.7 [Q05823-1]