Insufficient scRNA-seq data for expression of RNASEL at single-cell level.
Insufficient scRNA-seq data for expression of RNASEL at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 1425.10 | 653 / 653 | 100% | 13.63 | 603 / 605 |
breast | 99% | 928.82 | 456 / 459 | 99% | 12.16 | 1106 / 1118 |
lung | 99% | 1030.71 | 575 / 578 | 98% | 9.78 | 1137 / 1155 |
prostate | 100% | 1144.52 | 245 / 245 | 98% | 7.32 | 491 / 502 |
kidney | 99% | 868.18 | 88 / 89 | 99% | 10.28 | 891 / 901 |
esophagus | 100% | 988.91 | 1443 / 1445 | 98% | 8.57 | 179 / 183 |
bladder | 100% | 1226.52 | 21 / 21 | 97% | 8.41 | 490 / 504 |
stomach | 99% | 829.20 | 356 / 359 | 98% | 6.86 | 280 / 286 |
intestine | 100% | 1204.76 | 966 / 966 | 97% | 7.06 | 509 / 527 |
skin | 100% | 837.91 | 1807 / 1809 | 96% | 10.08 | 453 / 472 |
uterus | 100% | 1198.29 | 170 / 170 | 96% | 9.59 | 440 / 459 |
adrenal gland | 98% | 1082.41 | 254 / 258 | 95% | 7.97 | 219 / 230 |
pancreas | 94% | 368.98 | 307 / 328 | 99% | 11.89 | 176 / 178 |
brain | 89% | 396.15 | 2352 / 2642 | 98% | 7.01 | 693 / 705 |
ovary | 100% | 1550.93 | 180 / 180 | 72% | 3.05 | 309 / 430 |
liver | 73% | 209.38 | 166 / 226 | 51% | 2.27 | 209 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.98 | 29 / 29 |
spleen | 100% | 1613.71 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.52 | 1 / 1 |
adipose | 100% | 941.63 | 1200 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 911.99 | 1329 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 1494.93 | 901 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 11.40 | 43 / 45 |
heart | 93% | 406.82 | 797 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 5.12 | 73 / 80 |
muscle | 64% | 189.33 | 514 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045071 | Biological process | negative regulation of viral genome replication |
GO_0046326 | Biological process | positive regulation of glucose import |
GO_0006397 | Biological process | mRNA processing |
GO_0043488 | Biological process | regulation of mRNA stability |
GO_0006396 | Biological process | RNA processing |
GO_0051607 | Biological process | defense response to virus |
GO_0006468 | Biological process | protein phosphorylation |
GO_0006364 | Biological process | rRNA processing |
GO_0045444 | Biological process | fat cell differentiation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005575 | Cellular component | cellular_component |
GO_0016363 | Cellular component | nuclear matrix |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0004521 | Molecular function | RNA endonuclease activity |
GO_0019843 | Molecular function | rRNA binding |
GO_0043021 | Molecular function | ribonucleoprotein complex binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0004540 | Molecular function | RNA nuclease activity |
Gene name | RNASEL |
Protein name | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) |
Synonyms | RNS4 |
Description | FUNCTION: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis . Might play a central role in the regulation of mRNA turnover . Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. . |
Accessions | Q1RLL8 Q05823 ENST00000539397.1 [Q05823-2] ENST00000367559.7 [Q05823-1] |