Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 27% ± 6% | |
| natural killer cell | 4 studies | 23% ± 7% | |
| CD8-positive, alpha-beta T cell | 4 studies | 22% ± 1% | |
| deuterosomal cell | 3 studies | 19% ± 2% | |
| CD4-positive, alpha-beta T cell | 3 studies | 24% ± 1% |
Insufficient scRNA-seq data for expression of RNASEH2A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| uterus | 100% | 512.62 | 170 / 170 | 8% | 0.12 | 36 / 459 |
| ovary | 100% | 461.35 | 180 / 180 | 7% | 0.10 | 30 / 430 |
| bladder | 100% | 427.33 | 21 / 21 | 7% | 0.10 | 34 / 504 |
| stomach | 99% | 356.03 | 357 / 359 | 3% | 0.05 | 9 / 286 |
| esophagus | 99% | 474.54 | 1425 / 1445 | 3% | 0.04 | 5 / 183 |
| intestine | 99% | 427.66 | 958 / 966 | 2% | 0.03 | 9 / 527 |
| skin | 100% | 1011.91 | 1809 / 1809 | 1% | 0.01 | 4 / 472 |
| breast | 100% | 497.04 | 458 / 459 | 1% | 0.01 | 9 / 1118 |
| pancreas | 98% | 270.98 | 321 / 328 | 2% | 0.03 | 4 / 178 |
| spleen | 100% | 757.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| thymus | 99% | 435.83 | 649 / 653 | 0% | 0.01 | 3 / 605 |
| brain | 99% | 313.17 | 2623 / 2642 | 1% | 0.01 | 4 / 705 |
| prostate | 99% | 340.49 | 243 / 245 | 0% | 0.00 | 2 / 502 |
| adipose | 100% | 437.34 | 1198 / 1204 | 0% | 0 | 0 / 0 |
| lung | 95% | 408.41 | 549 / 578 | 3% | 0.05 | 38 / 1155 |
| adrenal gland | 98% | 341.16 | 253 / 258 | 0% | 0 | 0 / 230 |
| muscle | 97% | 265.04 | 781 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 236.07 | 835 / 861 | 0% | 0 | 0 / 0 |
| kidney | 97% | 338.92 | 86 / 89 | 0% | 0.01 | 1 / 901 |
| peripheral blood | 96% | 787.02 | 896 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 96% | 240.35 | 1277 / 1335 | 0% | 0 | 0 / 0 |
| liver | 88% | 196.97 | 200 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.23 | 4 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 0.12 | 4 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006298 | Biological process | mismatch repair |
| GO_0006401 | Biological process | RNA catabolic process |
| GO_0043137 | Biological process | DNA replication, removal of RNA primer |
| GO_0006260 | Biological process | DNA replication |
| GO_0032299 | Cellular component | ribonuclease H2 complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0004523 | Molecular function | RNA-DNA hybrid ribonuclease activity |
| GO_0004540 | Molecular function | RNA nuclease activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | RNASEH2A |
| Protein name | Ribonuclease (EC 3.1.26.4) Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) |
| Synonyms | RNASEHI RNHIA |
| Description | FUNCTION: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. . FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. . FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. . FUNCTION: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. .; FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. . |
| Accessions | ENST00000590121.2 O75792 ENST00000221486.6 A0A2R8Y658 Q6UQL6 A0A2R8Y606 ENST00000646769.1 |
