RNASE3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNASE3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNASE3 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227Biological processinnate immune response in mucosa
GO_0043152Biological processinduction of bacterial agglutination
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0006935Biological processchemotaxis
GO_0045087Biological processinnate immune response
GO_0019731Biological processantibacterial humoral response
GO_0006401Biological processRNA catabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0001530Molecular functionlipopolysaccharide binding
GO_0004540Molecular functionRNA nuclease activity
GO_0004519Molecular functionendonuclease activity
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameRNASE3
Protein nameEosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)
SynonymsECP
RNS3
DescriptionFUNCTION: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. .

AccessionsENST00000304639.4
P12724