RMI1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RMI1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RMI1 at tissue level.

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0035264Biological processmulticellular organism growth
GO_0071139Biological processresolution of DNA recombination intermediates
GO_0006260Biological processDNA replication
GO_0009749Biological processresponse to glucose
GO_0002023Biological processreduction of food intake in response to dietary excess
GO_0042593Biological processglucose homeostasis
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0031422Cellular componentRecQ family helicase-topoisomerase III complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0000166Molecular functionnucleotide binding

IV. Literature review

[source]
Gene nameRMI1
Protein nameRecQ-mediated genome instability protein 1
RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75)
SynonymsC9orf76
DescriptionFUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. .

AccessionsA0A0A0MSU3
ENST00000325875.7
Q9H9A7
ENST00000445877.6
ENST00000445877