RIOX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RIOX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RIOX1 at tissue level.

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0036139Molecular functionpeptidyl-histidine dioxygenase activity
GO_0140457Molecular functionprotein demethylase activity
GO_0005506Molecular functioniron ion binding
GO_0005515Molecular functionprotein binding
GO_0032453Molecular functionhistone H3K4 demethylase activity
GO_0140680Molecular functionhistone H3K36me/H3K36me2 demethylase activity
GO_0034647Molecular functionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity
GO_0051864Molecular functionhistone H3K36 demethylase activity
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity

IV. Literature review

[source]
Gene nameRIOX1
Protein nameRibosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)
SynonymsNO66
C14orf169
MAPJD
DescriptionFUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase . Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis . Participates in MYC-induced transcriptional activation . .

AccessionsQ9H6W3
ENST00000304061.8 [Q9H6W3-1]