RIOK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000234Biological processpositive regulation of rRNA processing
GO_0030490Biological processmaturation of SSU-rRNA
GO_0042274Biological processribosomal small subunit biogenesis
GO_0034708Cellular componentmethyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030688Cellular componentpreribosome, small subunit precursor
GO_0016787Molecular functionhydrolase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameRIOK1
Protein nameSerine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)
RIO kinase 1
SynonymsRIO1
DescriptionFUNCTION: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor . The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation . .

AccessionsENST00000379834.7
ENST00000475351.5
Q9BRS2
E9PFQ8