RING1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0016567Biological processprotein ubiquitination
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0048593Biological processcamera-type eye morphogenesis
GO_0009952Biological processanterior/posterior pattern specification
GO_0031519Cellular componentPcG protein complex
GO_0016607Cellular componentnuclear speck
GO_0001739Cellular componentsex chromatin
GO_0000151Cellular componentubiquitin ligase complex
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0097027Molecular functionubiquitin-protein transferase activator activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameRING1
Protein nameE3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
SynonymsRNF1
RING1A
DescriptionFUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. .

AccessionsENST00000383212.4 [Q06587-1]
Q06587
ENST00000436128.2 [Q06587-1]
ENST00000427374.2 [Q06587-1]
ENST00000430233.2 [Q06587-1]
ENST00000415941.2 [Q06587-1]
ENST00000374656.5 [Q06587-1]