RIDA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006402Biological processmRNA catabolic process
GO_1901565Biological processorganonitrogen compound catabolic process
GO_0061157Biological processmRNA destabilization
GO_0019518Biological processL-threonine catabolic process to glycine
GO_0006629Biological processlipid metabolic process
GO_0017148Biological processnegative regulation of translation
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0120242Molecular function2-iminobutanoate deaminase activity
GO_0019239Molecular functiondeaminase activity
GO_0003729Molecular functionmRNA binding
GO_0120243Molecular function2-iminopropanoate deaminase activity
GO_0016892Molecular functionRNA endonuclease activity, producing 3'-phosphomonoesters
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRIDA
Protein nameReactive intermediate imine deaminase A homolog
2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Translation inhibitor L-PSP ribonuclease)
2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (14.5 kDa translational inhibitor protein) (hp14.5) (p14.5) (Heat-responsive protein 12) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog)
SynonymsHRSP12
DescriptionFUNCTION: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. .; FUNCTION: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex . Acts by bridging YTHDF2 and the ribonuclease P/MRP complex . RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage . .

FUNCTION: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. .

FUNCTION: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. .

AccessionsH0YBX3
H0YB34
ENST00000520507.5
ENST00000254878.8
P52758
ENST00000521560.1
ENST00000522791.5
E5RIP8