RHCG | OmnibusX

Name	Number of supported studies	Average coverage
renal alpha-intercalated cell	7 studies	64% ± 25%	Explore
kidney connecting tubule epithelial cell	4 studies	75% ± 7%	Explore
basal cell	4 studies	34% ± 13%	Explore
squamous epithelial cell	3 studies	53% ± 33%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	49% ± 4%	Explore

Name	Number of supported studies	Average coverage
esophagus	3 studies	53% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	62%	133439.90	902 / 1445	68%	526.45	125 / 183
kidney	100%	8730.47	89 / 89	14%	167.57	127 / 901
skin	71%	1152.08	1293 / 1809	29%	16.17	138 / 472
tonsil	0%	0	0 / 0	98%	697.88	44 / 45
uterus	17%	3282.50	29 / 170	60%	337.64	275 / 459
brain	66%	165.43	1747 / 2642	4%	0.37	25 / 705
adrenal gland	53%	173.83	138 / 258	16%	29.08	37 / 230
pancreas	51%	150.50	166 / 328	13%	4.94	23 / 178
prostate	53%	356.66	131 / 245	6%	0.76	28 / 502
bladder	14%	45.86	3 / 21	37%	43.88	187 / 504
lung	5%	10.10	30 / 578	35%	58.15	402 / 1155
liver	22%	168.15	49 / 226	8%	2.25	31 / 406
breast	18%	61.98	84 / 459	11%	6.01	118 / 1118
intestine	10%	30.25	93 / 966	18%	69.87	93 / 527
stomach	12%	394.86	42 / 359	11%	1.44	32 / 286
ovary	11%	37.16	20 / 180	9%	1.14	39 / 430
heart	18%	45.87	151 / 861	0%	0	0 / 0
adipose	17%	106.78	200 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	16%	2.44	13 / 80
spleen	10%	30.20	23 / 241	0%	0	0 / 0
thymus	6%	33.91	38 / 653	2%	0.26	10 / 605
blood vessel	5%	24.38	73 / 1335	0%	0	0 / 0
peripheral blood	4%	24.40	38 / 929	0%	0	0 / 0
muscle	3%	50.70	24 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0035378	Biological process	carbon dioxide transmembrane transport
GO_0006873	Biological process	intracellular monoatomic ion homeostasis
GO_0030855	Biological process	epithelial cell differentiation
GO_0072488	Biological process	ammonium transmembrane transport
GO_0006885	Biological process	regulation of pH
GO_0097272	Biological process	ammonium homeostasis
GO_0015837	Biological process	amine transport
GO_0042592	Biological process	homeostatic process
GO_0070634	Biological process	transepithelial ammonium transport
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0070062	Cellular component	extracellular exosome
GO_0016323	Cellular component	basolateral plasma membrane
GO_0042802	Molecular function	identical protein binding
GO_0008519	Molecular function	ammonium channel activity
GO_0030506	Molecular function	ankyrin binding
GO_0005515	Molecular function	protein binding
GO_0035379	Molecular function	carbon dioxide transmembrane transporter activity

Gene name	RHCG
Protein name	Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2) Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein)
Synonyms	hCG_28640 PDRC2 CDRC2 RHGK C15orf6
Description	FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) . May act as a CO2 channel providing for renal acid secretion . .
Accessions	H0YM79 Q9UBD6 ENST00000649642.1 ENST00000560081.5 H0YMF8 ENST00000268122.9 H0YMS1 A0A3B3IT41 ENST00000558360.1 ENST00000558030.5 H0YKQ3 ENST00000558184.1

RHCG report