Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 16 studies | 30% ± 19% | |
microglial cell | 15 studies | 48% ± 18% | |
B cell | 14 studies | 23% ± 6% | |
memory B cell | 12 studies | 18% ± 4% | |
myeloid cell | 9 studies | 29% ± 12% | |
naive B cell | 7 studies | 21% ± 6% | |
non-classical monocyte | 5 studies | 22% ± 8% | |
plasmacytoid dendritic cell | 5 studies | 24% ± 6% | |
monocyte | 4 studies | 22% ± 6% | |
classical monocyte | 4 studies | 22% ± 5% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 19% ± 4% | |
precursor B cell | 4 studies | 29% ± 9% | |
immature B cell | 3 studies | 31% ± 11% | |
dendritic cell | 3 studies | 19% ± 3% | |
mononuclear phagocyte | 3 studies | 21% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 3 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 3838.17 | 577 / 578 | 99% | 27.24 | 1139 / 1155 |
ovary | 99% | 1171.12 | 178 / 180 | 100% | 29.88 | 428 / 430 |
breast | 100% | 2092.07 | 459 / 459 | 98% | 17.70 | 1092 / 1118 |
pancreas | 100% | 1732.00 | 327 / 328 | 97% | 26.70 | 173 / 178 |
stomach | 98% | 1182.37 | 353 / 359 | 98% | 24.40 | 281 / 286 |
thymus | 100% | 2011.71 | 652 / 653 | 96% | 12.31 | 582 / 605 |
kidney | 99% | 1775.88 | 88 / 89 | 96% | 25.22 | 867 / 901 |
skin | 96% | 2937.61 | 1732 / 1809 | 98% | 31.98 | 462 / 472 |
intestine | 94% | 1674.30 | 904 / 966 | 99% | 25.38 | 523 / 527 |
bladder | 95% | 1244.33 | 20 / 21 | 97% | 24.02 | 490 / 504 |
uterus | 96% | 1056.28 | 164 / 170 | 95% | 23.74 | 436 / 459 |
esophagus | 90% | 1670.37 | 1294 / 1445 | 100% | 38.09 | 183 / 183 |
prostate | 97% | 1556.44 | 238 / 245 | 47% | 3.53 | 238 / 502 |
brain | 54% | 715.71 | 1439 / 2642 | 89% | 18.46 | 627 / 705 |
liver | 67% | 539.35 | 151 / 226 | 70% | 12.26 | 285 / 406 |
adrenal gland | 100% | 1621.28 | 258 / 258 | 28% | 2.86 | 65 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 35.70 | 29 / 29 |
spleen | 100% | 6750.88 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2502.00 | 1203 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 5790.19 | 928 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 18.91 | 79 / 80 |
tonsil | 0% | 0 | 0 / 0 | 98% | 28.84 | 44 / 45 |
heart | 93% | 943.76 | 805 / 861 | 0% | 0 | 0 / 0 |
muscle | 86% | 1019.39 | 691 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 82% | 1066.56 | 1092 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0015031 | Biological process | protein transport |
GO_0050709 | Biological process | negative regulation of protein secretion |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0050708 | Biological process | regulation of protein secretion |
GO_0002862 | Biological process | negative regulation of inflammatory response to antigenic stimulus |
GO_0042058 | Biological process | regulation of epidermal growth factor receptor signaling pathway |
GO_0005796 | Cellular component | Golgi lumen |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
GO_0019838 | Molecular function | growth factor binding |
GO_0140318 | Molecular function | protein transporter activity |
Gene name | RHBDF2 |
Protein name | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) Inactive rhomboid protein (iRhom) (Rhomboid family member) (Rhomboid veinlet-like protein) Rhomboid 5 homolog 2 |
Synonyms | RHBDL6 RHBDL5 IRHOM2 |
Description | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. . FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. . |
Accessions | ENST00000313080.8 [Q6PJF5-1] ENST00000590288.1 ENST00000591697.5 K7ELA9 ENST00000585701.5 K7EKI1 K7EQT5 ENST00000590322.1 ENST00000589526.5 ENST00000591192.1 Q6PJF5 K7EPV3 ENST00000591255.5 ENST00000591879.1 ENST00000592123.5 ENST00000585989.5 K7EJD6 ENST00000591885.5 [Q6PJF5-2] ENST00000675367.1 [Q6PJF5-2] K7EPN8 K7EJ10 K7EKA3 ENST00000591860.1 K7EIY3 K7EQ53 |