RHBDF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0050709Biological processnegative regulation of protein secretion
GO_0072659Biological processprotein localization to plasma membrane
GO_0050708Biological processregulation of protein secretion
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0005796Cellular componentGolgi lumen
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0019838Molecular functiongrowth factor binding
GO_0140318Molecular functionprotein transporter activity

IV. Literature review

[source]
Gene nameRHBDF2
Protein nameInactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)
Inactive rhomboid protein (iRhom) (Rhomboid family member) (Rhomboid veinlet-like protein)
Rhomboid 5 homolog 2
SynonymsRHBDL6
RHBDL5
IRHOM2
DescriptionFUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

AccessionsENST00000313080.8 [Q6PJF5-1]
ENST00000590288.1
ENST00000591697.5
K7ELA9
ENST00000585701.5
K7EKI1
K7EQT5
ENST00000590322.1
ENST00000589526.5
ENST00000591192.1
Q6PJF5
K7EPV3
ENST00000591255.5
ENST00000591879.1
ENST00000592123.5
ENST00000585989.5
K7EJD6
ENST00000591885.5 [Q6PJF5-2]
ENST00000675367.1 [Q6PJF5-2]
K7EPN8
K7EJ10
K7EKA3
ENST00000591860.1
K7EIY3
K7EQ53