Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 16 studies | 47% ± 19% | |
| glutamatergic neuron | 13 studies | 38% ± 24% | |
| adipocyte | 9 studies | 28% ± 9% | |
| GABAergic neuron | 8 studies | 37% ± 19% | |
| astrocyte | 7 studies | 30% ± 13% | |
| retinal ganglion cell | 7 studies | 54% ± 24% | |
| epithelial cell of proximal tubule | 6 studies | 22% ± 4% | |
| neuron | 6 studies | 31% ± 14% | |
| retina horizontal cell | 6 studies | 33% ± 5% | |
| epithelial cell | 6 studies | 31% ± 10% | |
| type I pneumocyte | 5 studies | 23% ± 8% | |
| podocyte | 5 studies | 54% ± 17% | |
| cardiac muscle cell | 5 studies | 59% ± 11% | |
| interneuron | 5 studies | 40% ± 20% | |
| lymphocyte | 4 studies | 21% ± 3% | |
| OFF-bipolar cell | 4 studies | 38% ± 17% | |
| T cell | 4 studies | 19% ± 3% | |
| retinal bipolar neuron | 3 studies | 18% ± 2% | |
| glial cell | 3 studies | 28% ± 10% | |
| mesothelial cell | 3 studies | 32% ± 8% | |
| rod bipolar cell | 3 studies | 17% ± 2% | |
| ependymal cell | 3 studies | 37% ± 12% | |
| group 3 innate lymphoid cell | 3 studies | 19% ± 2% | |
| Schwann cell | 3 studies | 48% ± 18% | |
| granule cell | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 2185.42 | 2594 / 2642 | 99% | 34.99 | 695 / 705 |
| kidney | 98% | 3113.00 | 87 / 89 | 99% | 87.33 | 888 / 901 |
| thymus | 91% | 805.49 | 597 / 653 | 96% | 19.04 | 581 / 605 |
| breast | 99% | 2116.37 | 453 / 459 | 86% | 37.15 | 959 / 1118 |
| pancreas | 99% | 1488.77 | 325 / 328 | 84% | 18.14 | 149 / 178 |
| intestine | 95% | 1363.25 | 917 / 966 | 88% | 21.60 | 462 / 527 |
| stomach | 94% | 1393.73 | 337 / 359 | 88% | 22.25 | 253 / 286 |
| prostate | 80% | 730.86 | 195 / 245 | 97% | 22.65 | 488 / 502 |
| lung | 90% | 1149.42 | 519 / 578 | 57% | 9.63 | 655 / 1155 |
| liver | 88% | 1525.12 | 198 / 226 | 40% | 8.12 | 163 / 406 |
| skin | 72% | 1060.64 | 1294 / 1809 | 55% | 12.33 | 258 / 472 |
| esophagus | 56% | 494.46 | 807 / 1445 | 66% | 15.74 | 120 / 183 |
| muscle | 100% | 14580.31 | 800 / 803 | 0% | 0 | 0 / 0 |
| adipose | 99% | 2410.80 | 1191 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 5579.78 | 842 / 861 | 0% | 0 | 0 / 0 |
| bladder | 38% | 215.38 | 8 / 21 | 32% | 6.80 | 161 / 504 |
| adrenal gland | 3% | 40.28 | 8 / 258 | 66% | 13.93 | 152 / 230 |
| uterus | 26% | 192.04 | 44 / 170 | 31% | 4.65 | 142 / 459 |
| blood vessel | 51% | 490.91 | 681 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 8% | 52.24 | 15 / 180 | 34% | 4.31 | 148 / 430 |
| eye | 0% | 0 | 0 / 0 | 29% | 3.08 | 23 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 4.73 | 11 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 1.75 | 4 / 29 |
| peripheral blood | 10% | 72.93 | 91 / 929 | 0% | 0 | 0 / 0 |
| spleen | 3% | 18.43 | 8 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0007029 | Biological process | endoplasmic reticulum organization |
| GO_0000423 | Biological process | mitophagy |
| GO_0061709 | Biological process | reticulophagy |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0050872 | Biological process | white fat cell differentiation |
| GO_0030574 | Biological process | collagen catabolic process |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005801 | Cellular component | cis-Golgi network |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0140506 | Molecular function | endoplasmic reticulum-autophagosome adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RETREG1 |
| Protein name | Reticulophagy regulator 1 Reticulophagy regulator 1 (Reticulophagy receptor 1) |
| Synonyms | FAM134B JK1 |
| Description | FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes . Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins . Active under basal conditions . Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons . .; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein . This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection . . |
| Accessions | ENST00000684456.1 ENST00000683527.1 ENST00000682033.1 A0A804HJ37 ENST00000683539.1 ENST00000510362.6 A0A804HKW5 ENST00000683130.1 ENST00000399793.6 [Q9H6L5-2] Q9H6L5 A0A804HHX5 ENST00000306320.10 [Q9H6L5-1] A0A804HIW5 A0A804HJZ6 A0A804HIV2 A0A804HJI9 ENST00000682142.1 ENST00000682628.1 ENST00000683414.1 ENST00000682564.1 H0Y9U4 ENST00000684521.1 A0A804HKT1 ENST00000682229.1 |