RETREG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0007029Biological processendoplasmic reticulum organization
GO_0000423Biological processmitophagy
GO_0061709Biological processreticulophagy
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0050872Biological processwhite fat cell differentiation
GO_0030574Biological processcollagen catabolic process
GO_0005730Cellular componentnucleolus
GO_0005801Cellular componentcis-Golgi network
GO_0016604Cellular componentnuclear body
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140506Molecular functionendoplasmic reticulum-autophagosome adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRETREG1
Protein nameReticulophagy regulator 1
Reticulophagy regulator 1 (Reticulophagy receptor 1)
SynonymsFAM134B
JK1
DescriptionFUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes . Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins . Active under basal conditions . Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons . .; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein . This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection . .

AccessionsENST00000684456.1
ENST00000683527.1
ENST00000682033.1
A0A804HJ37
ENST00000683539.1
ENST00000510362.6
A0A804HKW5
ENST00000683130.1
ENST00000399793.6 [Q9H6L5-2]
Q9H6L5
A0A804HHX5
ENST00000306320.10 [Q9H6L5-1]
A0A804HIW5
A0A804HJZ6
A0A804HIV2
A0A804HJI9
ENST00000682142.1
ENST00000682628.1
ENST00000683414.1
ENST00000682564.1
H0Y9U4
ENST00000684521.1
A0A804HKT1
ENST00000682229.1