I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 8 studies | 48% ± 16% | |
| retinal cone cell | 6 studies | 37% ± 21% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal rod cell | 8 studies | 48% ± 16% | |
| retinal cone cell | 6 studies | 37% ± 21% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 6 studies | 31% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 72% | 3502.64 | 1297 / 1809 | 40% | 4.41 | 188 / 472 |
| liver | 30% | 72.74 | 68 / 226 | 74% | 3.96 | 302 / 406 |
| esophagus | 38% | 594.80 | 551 / 1445 | 55% | 4.04 | 101 / 183 |
| prostate | 9% | 16.58 | 23 / 245 | 81% | 3.52 | 407 / 502 |
| adrenal gland | 57% | 295.50 | 148 / 258 | 28% | 1.57 | 65 / 230 |
| pancreas | 27% | 60.38 | 90 / 328 | 55% | 3.82 | 98 / 178 |
| kidney | 37% | 136.60 | 33 / 89 | 40% | 1.89 | 358 / 901 |
| stomach | 54% | 444.43 | 193 / 359 | 22% | 0.69 | 64 / 286 |
| thymus | 20% | 50.92 | 128 / 653 | 35% | 1.11 | 212 / 605 |
| brain | 17% | 43.16 | 456 / 2642 | 21% | 0.40 | 151 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 2.66 | 15 / 45 |
| uterus | 1% | 32.49 | 2 / 170 | 31% | 2.51 | 140 / 459 |
| bladder | 0% | 0 | 0 / 21 | 25% | 1.24 | 128 / 504 |
| lung | 0% | 0.66 | 2 / 578 | 21% | 0.91 | 238 / 1155 |
| intestine | 0% | 0.26 | 1 / 966 | 17% | 0.82 | 89 / 527 |
| ovary | 0% | 0 | 0 / 180 | 12% | 0.23 | 50 / 430 |
| eye | 0% | 0 | 0 / 0 | 6% | 1.70 | 5 / 80 |
| breast | 0% | 0 | 0 / 459 | 5% | 0.23 | 61 / 1118 |
| adipose | 1% | 4.91 | 8 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 2.15 | 3 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 1.27 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045494 | Biological process | photoreceptor cell maintenance |
| GO_0007601 | Biological process | visual perception |
| GO_0001523 | Biological process | retinoid metabolic process |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0110095 | Biological process | cellular detoxification of aldehyde |
| GO_0001917 | Cellular component | photoreceptor inner segment |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0060342 | Cellular component | photoreceptor inner segment membrane |
| GO_0004745 | Molecular function | all-trans-retinol dehydrogenase (NAD+) activity |
| GO_0102354 | Molecular function | 11-cis-retinol dehydrogenase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0052650 | Molecular function | all-trans-retinol dehydrogenase (NADP+) activity |
| Gene name | RDH12 |
| Protein name | Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2) Retinol dehydrogenase 12 isoform 1 Retinol dehydrogenase 12 isoform 4 |
| Synonyms | SDR7C2 |
| Description | FUNCTION: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol . Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal . May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation . Has no dehydrogenase activity towards steroids . . |
| Accessions | A0A0S2Z5W8 ENST00000267502.3 ENST00000551171.6 A0A0S2Z613 Q96NR8 |
