RCN3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RCN3 at tissue level.

III. Associated gene sets

GO_0060428Biological processlung epithelium development
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0015031Biological processprotein transport
GO_0055091Biological processphospholipid homeostasis
GO_0032964Biological processcollagen biosynthetic process
GO_0010952Biological processpositive regulation of peptidase activity
GO_0036503Biological processERAD pathway
GO_0043129Biological processsurfactant homeostasis
GO_0009306Biological processprotein secretion
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRCN3
Protein nameReticulocalbin 3
Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
SynonymsUNQ239/PRO272
DescriptionFUNCTION: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum . Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens . This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion . .

AccessionsQ96D15
M0QZH0
ENST00000270645.8
ENST00000593483.1
M0QZU3
ENST00000597801.1
ENST00000598833.1
M0QYB8