RBM24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905870Biological processpositive regulation of 3'-UTR-mediated mRNA stabilization
GO_0006397Biological processmRNA processing
GO_0043488Biological processregulation of mRNA stability
GO_0006974Biological processDNA damage response
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0061157Biological processmRNA destabilization
GO_0048255Biological processmRNA stabilization
GO_0010830Biological processregulation of myotube differentiation
GO_2000766Biological processnegative regulation of cytoplasmic translation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_1902811Biological processpositive regulation of skeletal muscle fiber differentiation
GO_0010831Biological processpositive regulation of myotube differentiation
GO_0008380Biological processRNA splicing
GO_0030154Biological processcell differentiation
GO_0003197Biological processendocardial cushion development
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_1990825Molecular functionsequence-specific mRNA binding
GO_0097157Molecular functionpre-mRNA intronic binding
GO_1990715Molecular functionmRNA CDS binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBM24
Protein nameRNA binding motif protein 24, isoform CRA_a (cDNA FLJ76592) (cDNA, FLJ79505, highly similar to RNA-binding region-containing protein 1)
RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6)
RNA binding motif protein 24
SynonymshCG_1642676
RNPC6
DescriptionFUNCTION: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation . Plays a major role in pre-mRNA alternative splicing regulation . Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation . Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes . Plays a role in the regulation of mRNA stability . Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities . Involved in myogenic differentiation by regulating MYOG levels . Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization . Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence . Plays a role in the regulation of mRNA translation . Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation . Binds to a huge amount of mRNAs . Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). .; FUNCTION: (Microbial infection) Promotes hepatitis C virus (HCV) replication over translation through the inhibition of viral protein expression. Decreases viral translation by linking viral 5'- and 3'-UTRs, blocking 80S ribosome assembly on the viral IRES and enhancing the interaction of the mature core protein and 5'-UTR. .

AccessionsH0YA61
A8KAI7
H0Y8S7
ENST00000425446.6 [Q9BX46-5]
ENST00000318204.5 [Q9BX46-2]
ENST00000379052.10 [Q9BX46-1]
Q9BX46
ENST00000503965.5
ENST00000509686.5