RBM20 | OmnibusX

Name	Number of supported studies	Average coverage
heart	5 studies	35% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	78%	389.31	512 / 653	30%	0.74	180 / 605
uterus	87%	1004.15	148 / 170	21%	1.34	95 / 459
ovary	95%	900.27	171 / 180	10%	0.25	44 / 430
esophagus	83%	1049.73	1202 / 1445	19%	0.45	35 / 183
pancreas	95%	4261.33	312 / 328	7%	0.12	12 / 178
muscle	100%	2537.62	803 / 803	0%	0	0 / 0
heart	99%	8041.10	853 / 861	0%	0	0 / 0
kidney	30%	109.03	27 / 89	66%	2.48	595 / 901
skin	44%	247.70	805 / 1809	44%	2.37	206 / 472
intestine	74%	911.00	714 / 966	3%	0.06	14 / 527
breast	46%	240.53	211 / 459	30%	2.64	334 / 1118
eye	0%	0	0 / 0	74%	2.72	59 / 80
blood vessel	73%	1266.47	978 / 1335	0%	0	0 / 0
prostate	64%	490.06	158 / 245	7%	0.15	36 / 502
bladder	62%	349.95	13 / 21	8%	0.33	42 / 504
adipose	64%	377.35	775 / 1204	0%	0	0 / 0
stomach	50%	229.03	178 / 359	6%	0.27	17 / 286
lung	33%	256.20	192 / 578	12%	0.37	141 / 1155
brain	20%	101.27	530 / 2642	19%	0.32	135 / 705
adrenal gland	0%	1.38	1 / 258	19%	0.40	43 / 230
tonsil	0%	0	0 / 0	18%	0.31	8 / 45
lymph node	0%	0	0 / 0	14%	0.45	4 / 29
liver	0%	0	0 / 226	8%	0.20	32 / 406
peripheral blood	1%	2.92	8 / 929	0%	0	0 / 0
spleen	0%	1.40	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043484	Biological process	regulation of RNA splicing
GO_0033120	Biological process	positive regulation of RNA splicing
GO_0048025	Biological process	negative regulation of mRNA splicing, via spliceosome
GO_0060914	Biological process	heart formation
GO_0008380	Biological process	RNA splicing
GO_0048024	Biological process	regulation of mRNA splicing, via spliceosome
GO_0006397	Biological process	mRNA processing
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0005634	Cellular component	nucleus
GO_0097157	Molecular function	pre-mRNA intronic binding
GO_1990935	Molecular function	splicing factor binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0008270	Molecular function	zinc ion binding
GO_0003723	Molecular function	RNA binding

Gene name	RBM20
Protein name	RNA binding motif protein 20 Truncated RNA binding motif protein 20 RNA-binding protein 20 (RNA-binding motif protein 20)
Synonyms
Description	FUNCTION: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH . Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts . RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles . RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts . Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). .
Accessions	Q5T481 ENST00000369519.4 A0A7R6RR32 A0A7R6M6R7 A0A7R6M8M5 A0A7R6RQJ6

RBM20 report