RADX report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RADX at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RADX at tissue level.

III. Associated gene sets

GO_0006282Biological processregulation of DNA repair
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0016607Cellular componentnuclear speck
GO_0005657Cellular componentreplication fork
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding
GO_0003697Molecular functionsingle-stranded DNA binding

IV. Literature review

[source]
Gene nameRADX
Protein nameRPA-related protein RADX (RPA-related and RAD51-antagonist, X-chromosome)
RPA1 related single stranded DNA binding protein, X-linked
SynonymsCXorf57
DescriptionFUNCTION: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability . Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks . .

AccessionsB1AQ74
ENST00000372544.6 [Q6NSI4-4]
Q6NSI4
ENST00000461251.5 [Q6NSI4-2]
ENST00000372548.9 [Q6NSI4-1]
ENST00000421550.1