RAB7B | OmnibusX

Name	Number of supported studies	Average coverage
dendritic cell	3 studies	27% ± 13%	Explore
conventional dendritic cell	3 studies	24% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAB7B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	98%	1149.68	643 / 653	92%	15.38	555 / 605
skin	100%	2503.79	1802 / 1809	90%	19.19	423 / 472
lung	98%	852.20	565 / 578	88%	22.84	1022 / 1155
uterus	95%	917.29	162 / 170	86%	25.80	394 / 459
breast	83%	649.54	382 / 459	82%	9.44	918 / 1118
prostate	93%	824.67	227 / 245	66%	4.47	333 / 502
esophagus	66%	1008.33	958 / 1445	75%	13.66	138 / 183
bladder	81%	734.33	17 / 21	57%	8.58	289 / 504
ovary	72%	300.79	129 / 180	62%	4.54	266 / 430
stomach	83%	450.57	298 / 359	50%	2.80	143 / 286
pancreas	9%	30.09	29 / 328	89%	12.63	159 / 178
tonsil	0%	0	0 / 0	93%	33.06	42 / 45
brain	27%	138.79	712 / 2642	66%	6.64	468 / 705
adipose	91%	983.35	1091 / 1204	0%	0	0 / 0
intestine	46%	200.69	440 / 966	36%	2.66	189 / 527
blood vessel	78%	499.72	1046 / 1335	0%	0	0 / 0
kidney	9%	20.74	8 / 89	69%	5.00	620 / 901
lymph node	0%	0	0 / 0	59%	4.67	17 / 29
heart	55%	277.59	471 / 861	0%	0	0 / 0
spleen	47%	172.88	114 / 241	0%	0	0 / 0
liver	3%	10.93	6 / 226	33%	2.74	134 / 406
adrenal gland	10%	27.52	25 / 258	15%	1.03	35 / 230
muscle	14%	49.18	116 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	6%	0.41	5 / 80
peripheral blood	2%	7.17	14 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045654	Biological process	positive regulation of megakaryocyte differentiation
GO_0034144	Biological process	negative regulation of toll-like receptor 4 signaling pathway
GO_0034499	Biological process	late endosome to Golgi transport
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0090385	Biological process	phagosome-lysosome fusion
GO_0008333	Biological process	endosome to lysosome transport
GO_0034164	Biological process	negative regulation of toll-like receptor 9 signaling pathway
GO_0015031	Biological process	protein transport
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0071346	Biological process	cellular response to type II interferon
GO_0031902	Cellular component	late endosome membrane
GO_0005764	Cellular component	lysosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005802	Cellular component	trans-Golgi network
GO_0045335	Cellular component	phagocytic vesicle
GO_0005770	Cellular component	late endosome
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

Gene name	RAB7B
Protein name	RAB7B, member RAS oncogene family Ras-related protein Rab-7b
Synonyms
Description	FUNCTION: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. .
Accessions	ENST00000623893.1 A0A096LPF0 ENST00000617991.4 ENST00000623597.3 ENST00000622969.1 Q96AH8 ENST00000617070.5 A0A096LP44

RAB7B report