RAB2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0015031Biological processprotein transport
GO_0016192Biological processvesicle-mediated transport
GO_0007030Biological processGolgi organization
GO_0016236Biological processmacroautophagy
GO_0032481Biological processpositive regulation of type I interferon production
GO_0045921Biological processpositive regulation of exocytosis
GO_0045087Biological processinnate immune response
GO_0000139Cellular componentGolgi membrane
GO_0000421Cellular componentautophagosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0001669Cellular componentacrosomal vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB2B
Protein nameGTP-binding protein RAB2B
RAB2B, member RAS oncogene family
Ras-related protein Rab-2B (EC 3.6.5.2)
Synonyms
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). .

AccessionsENST00000649801.1
E9PE37
Q9UL31
A0A3B3ITL1
ENST00000397762.6 [Q8WUD1-1]
ENST00000417141.5
Q8WUD1