RAB11FIP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061512Biological processprotein localization to cilium
GO_0070164Biological processnegative regulation of adiponectin secretion
GO_0060627Biological processregulation of vesicle-mediated transport
GO_0051301Biological processcell division
GO_1903438Biological processpositive regulation of mitotic cytokinetic process
GO_1902017Biological processregulation of cilium assembly
GO_0032456Biological processendocytic recycling
GO_0061502Biological processearly endosome to recycling endosome transport
GO_0016192Biological processvesicle-mediated transport
GO_1902954Biological processregulation of early endosome to recycling endosome transport
GO_0045724Biological processpositive regulation of cilium assembly
GO_1905345Biological processprotein localization to cleavage furrow
GO_1904779Biological processregulation of protein localization to centrosome
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_2001135Biological processregulation of endocytic recycling
GO_0032465Biological processregulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0034451Cellular componentcentriolar satellite
GO_0030139Cellular componentendocytic vesicle
GO_0055037Cellular componentrecycling endosome
GO_0005739Cellular componentmitochondrion
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005813Cellular componentcentrosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0032154Cellular componentcleavage furrow
GO_0005768Cellular componentendosome
GO_0098944Cellular componentpostsynaptic recycling endosome membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAB11FIP3
Protein nameRAB11 family interacting protein 3
Rab11 family-interacting protein 3
Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148)
SynonymsKIAA0665
ARFO1
DescriptionFUNCTION: Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery . Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex . The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle . Facilitates the interaction between dynein and dynactin and activates dynein processivity . Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission . The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes . Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation . Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin . Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway . May play a role in breast cancer cell motility by regulating actin cytoskeleton . .

AccessionsENST00000449879.6
A0A0J9YY48
O75154
A0A0J9YWV4
A0A0J9YWM0
ENST00000611004.4 [O75154-1]
ENST00000450428.5 [O75154-2]
ENST00000434585.6 [O75154-3]
H0Y7F9
ENST00000633920.1
ENST00000633334.1
ENST00000262305.9 [O75154-1]
ENST00000434585.6
X6RFI8
ENST00000452814.5
A0A0J9YXZ3
ENST00000412256.1
ENST00000632539.1
F6X994
A0A0A0MSV1
ENST00000631977.1
ENST00000610934.1 [O75154-2]