PTS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006729Biological processtetrahydrobiopterin biosynthetic process
GO_0006520Biological processamino acid metabolic process
GO_0007417Biological processcentral nervous system development
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0003874Molecular function6-pyruvoyltetrahydropterin synthase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePTS
Protein name6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12)
6-pyruvoyltetrahydropterin synthase (EC 4.2.3.12)
6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12)
SynonymsPTPS
DescriptionFUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. .

FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. .

AccessionsENST00000280362.8
E9PKY8
E9PNN3
E9PJM0
ENST00000524931.1
ENST00000528679.5
ENST00000531673.5
Q03393
ENST00000525803.1