Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 53 studies | 53% ± 21% | |
capillary endothelial cell | 16 studies | 44% ± 16% | |
endothelial cell of artery | 15 studies | 66% ± 17% | |
vein endothelial cell | 15 studies | 57% ± 22% | |
endothelial cell of lymphatic vessel | 13 studies | 34% ± 16% | |
endothelial cell of vascular tree | 10 studies | 47% ± 24% | |
glutamatergic neuron | 6 studies | 41% ± 24% | |
GABAergic neuron | 6 studies | 33% ± 15% | |
pericyte | 5 studies | 35% ± 17% | |
endothelial cell of sinusoid | 4 studies | 64% ± 8% | |
glomerular endothelial cell | 4 studies | 86% ± 2% | |
endocardial cell | 3 studies | 41% ± 15% | |
interneuron | 3 studies | 38% ± 12% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 3 studies | 47% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 3229.42 | 962 / 966 | 96% | 7.12 | 504 / 527 |
stomach | 93% | 1824.05 | 335 / 359 | 97% | 7.42 | 278 / 286 |
thymus | 100% | 5708.14 | 653 / 653 | 89% | 8.94 | 539 / 605 |
brain | 94% | 1897.15 | 2488 / 2642 | 91% | 8.42 | 645 / 705 |
breast | 100% | 6984.85 | 459 / 459 | 85% | 5.88 | 953 / 1118 |
prostate | 98% | 2762.67 | 241 / 245 | 84% | 4.77 | 424 / 502 |
lung | 100% | 12340.11 | 578 / 578 | 82% | 5.70 | 952 / 1155 |
kidney | 100% | 4943.58 | 89 / 89 | 78% | 19.46 | 705 / 901 |
adrenal gland | 99% | 2930.14 | 256 / 258 | 76% | 7.05 | 175 / 230 |
bladder | 95% | 2214.76 | 20 / 21 | 72% | 4.08 | 361 / 504 |
esophagus | 87% | 2327.52 | 1260 / 1445 | 78% | 5.74 | 143 / 183 |
uterus | 99% | 4294.73 | 168 / 170 | 49% | 2.20 | 226 / 459 |
pancreas | 48% | 536.96 | 159 / 328 | 94% | 7.56 | 168 / 178 |
liver | 53% | 860.32 | 119 / 226 | 55% | 2.47 | 222 / 406 |
skin | 53% | 835.11 | 957 / 1809 | 52% | 2.44 | 247 / 472 |
adipose | 100% | 8187.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 8131.45 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 100% | 3968.05 | 859 / 861 | 0% | 0 | 0 / 0 |
muscle | 95% | 1710.69 | 763 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 83% | 2095.23 | 1106 / 1335 | 0% | 0 | 0 / 0 |
ovary | 68% | 1421.67 | 122 / 180 | 15% | 0.44 | 64 / 430 |
tonsil | 0% | 0 | 0 / 0 | 44% | 1.88 | 20 / 45 |
eye | 0% | 0 | 0 / 0 | 36% | 1.81 | 29 / 80 |
lymph node | 0% | 0 | 0 / 0 | 24% | 0.64 | 7 / 29 |
peripheral blood | 0% | 4.57 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0001525 | Biological process | angiogenesis |
GO_0006796 | Biological process | phosphate-containing compound metabolic process |
GO_0006470 | Biological process | protein dephosphorylation |
GO_1990264 | Biological process | peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
GO_0016311 | Biological process | dephosphorylation |
GO_0008347 | Biological process | glial cell migration |
GO_0070821 | Cellular component | tertiary granule membrane |
GO_0043235 | Cellular component | receptor complex |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005001 | Molecular function | transmembrane receptor protein tyrosine phosphatase activity |
GO_0045296 | Molecular function | cadherin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PTPRB |
Protein name | Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Protein tyrosine phosphatase receptor type B (cDNA FLJ46721 fis, clone TRACH3018524, highly similar to Protein-tyrosine phosphatase beta) Protein tyrosine phosphatase receptor type B PTPRB protein protein-tyrosine-phosphatase (EC 3.1.3.48) |
Synonyms | PTPB |
Description | FUNCTION: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). . |
Accessions | F8VSD5 ENST00000548122.2 P23467 ENST00000550857.5 [P23467-2] ENST00000261266.9 [P23467-1] ENST00000551525.5 ENST00000538708.5 [P23467-4] ENST00000547715.1 ENST00000334414.11 [P23467-3] ENST00000550358.5 Q6ZR19 Q86VA4 H0YHE8 F8VU56 |