PTPRB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0006796Biological processphosphate-containing compound metabolic process
GO_0006470Biological processprotein dephosphorylation
GO_1990264Biological processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0016311Biological processdephosphorylation
GO_0008347Biological processglial cell migration
GO_0070821Cellular componenttertiary granule membrane
GO_0043235Cellular componentreceptor complex
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0005001Molecular functiontransmembrane receptor protein tyrosine phosphatase activity
GO_0045296Molecular functioncadherin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTPRB
Protein nameReceptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Protein tyrosine phosphatase receptor type B (cDNA FLJ46721 fis, clone TRACH3018524, highly similar to Protein-tyrosine phosphatase beta)
Protein tyrosine phosphatase receptor type B
PTPRB protein
protein-tyrosine-phosphatase (EC 3.1.3.48)
SynonymsPTPB
DescriptionFUNCTION: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). .

AccessionsF8VSD5
ENST00000548122.2
P23467
ENST00000550857.5 [P23467-2]
ENST00000261266.9 [P23467-1]
ENST00000551525.5
ENST00000538708.5 [P23467-4]
ENST00000547715.1
ENST00000334414.11 [P23467-3]
ENST00000550358.5
Q6ZR19
Q86VA4
H0YHE8
F8VU56