PTGS1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTGS1 at tissue level.

III. Associated gene sets

GO_0019371Biological processcyclooxygenase pathway
GO_0098869Biological processcellular oxidant detoxification
GO_0008217Biological processregulation of blood pressure
GO_0001516Biological processprostaglandin biosynthetic process
GO_0006979Biological processresponse to oxidative stress
GO_0042127Biological processregulation of cell population proliferation
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0004601Molecular functionperoxidase activity
GO_0004666Molecular functionprostaglandin-endoperoxide synthase activity
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0016702Molecular functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IV. Literature review

[source]
Gene namePTGS1
Protein nameProstaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1)
Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (Prostaglandin H2 synthase 1) (Prostaglandin-endoperoxide synthase 1)
Prostaglandin-endoperoxide synthase 1
Cyclooxygenase-1 (EC 1.14.99.1)
SynonymsCOX1
DescriptionFUNCTION: Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons . Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). .

AccessionsENST00000362012.7 [P23219-1]
ENST00000223423.8 [P23219-2]
A0A2R8YDM0
ENST00000643810.1
ENST00000647067.1
X6RJD6
ENST00000426608.6
A0A2R8Y6S0
ENST00000373698.7 [P23219-4]
ENST00000619306.5
ENST00000540753.6 [P23219-3]
A0A087X296
Q6LCE7
P23219