PTF1A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PTF1A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTF1A at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0009888Biological processtissue development
GO_0031016Biological processpancreas development
GO_0032502Biological processdevelopmental process
GO_0048663Biological processneuron fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031017Biological processexocrine pancreas development
GO_0061074Biological processregulation of neural retina development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0021549Biological processcerebellum development
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0035881Biological processamacrine cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0010842Biological processretina layer formation
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity

IV. Literature review

[source]
Gene namePTF1A
Protein namePancreas associated transcription factor 1a
Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
SynonymsPTF1P48
BHLHA29
DescriptionFUNCTION: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. .

AccessionsENST00000639082.1
ENST00000640697.1
A0A1W2PR29
A0A1W2PQF5
ENST00000638469.1
A0A1W2PQC4
A0A1W2PRT5
A0A1W2PPH2
ENST00000639873.1
Q7RTS3
ENST00000640579.1
ENST00000376504.4