PPP2R2D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051301Biological processcell division
GO_0000278Biological processmitotic cell cycle
GO_0010458Biological processexit from mitosis
GO_0000159Cellular componentprotein phosphatase type 2A complex
GO_0005829Cellular componentcytosol
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP2R2D
Protein nameProtein phosphatase 2 regulatory subunit Bdelta
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
SynonymshCG_23640
KIAA1541
DescriptionFUNCTION: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). .

AccessionsENST00000616467.4
Q6IN90
ENST00000470416.5
A0A3B3IRK1
A0A0A6YYD6
Q66LE6
ENST00000482010.6
A0A096LPI9
ENST00000649083.1
Q6PEG1
ENST00000455566.6
H0YB06