POMGNT2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POMGNT2 at tissue level.

III. Associated gene sets

GO_0001764Biological processneuron migration
GO_0006493Biological processprotein O-linked glycosylation
GO_0035269Biological processprotein O-linked mannosylation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097363Molecular functionprotein O-acetylglucosaminyltransferase activity
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOMGNT2
Protein nameProtein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)
SynonymsGTDC2
AGO61
EOGTL
C3orf39
DescriptionFUNCTION: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. .

AccessionsQ8NAT1
ENST00000687440.1
ENST00000689987.1
ENST00000692017.1
ENST00000693717.1
ENST00000344697.3
ENST00000686643.1
ENST00000441964.1