POLR3G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0006359Biological processregulation of transcription by RNA polymerase III
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0045089Biological processpositive regulation of innate immune response
GO_0008283Biological processcell population proliferation
GO_0006383Biological processtranscription by RNA polymerase III
GO_0045087Biological processinnate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016604Cellular componentnuclear body
GO_0005666Cellular componentRNA polymerase III complex
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0005515Molecular functionprotein binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR3G
Protein nameAlternative protein POLR3G
RNA polymerase III subunit G
DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32)
Synonyms
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci . Acts as a long tether that bridges POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription . Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway . .

AccessionsA0A7I2R591
D6RJH6
ENST00000504930.5
ENST00000514483.5
L8E8B4
ENST00000503373.5
D6REQ0
D6R9U7
ENST00000505345.5
ENST00000399107.6
ENST00000512239.1
ENST00000651687.1
D6RIT0
O15318