POLR3F report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0006359Biological processregulation of transcription by RNA polymerase III
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0045089Biological processpositive regulation of innate immune response
GO_0006383Biological processtranscription by RNA polymerase III
GO_0045087Biological processinnate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR3F
Protein nameRNA polymerase III subunit F
Alternative protein POLR3F
DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39)
DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6)
SynonymshCG_21130
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state . Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway . Preferentially binds double-stranded DNA (dsDNA) . .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. .

AccessionsA0A8V8TL66
A0A8V8TMS0
ENST00000377603.5
ENST00000697656.1
ENST00000697653.1
ENST00000697654.1
ENST00000697658.1
ENST00000697649.1
ENST00000697652.1
ENST00000697650.1
ENST00000697655.1
A0A8V8TL69
A0A8V8TL74
ENST00000462997.6
Q9H1D9
A0A8V8TLJ3
A0A8V8TMS5
ENST00000697657.1
ENST00000697651.1
Q05DB8
ENST00000489753.1
ENST00000497333.5
A0A8V8TLI4
A0A8V8TMT0
ENST00000697645.1
A0A8V8TMJ7
A0A8V8TL45
A0A8V8TMI8
ENST00000697647.1
A0A8V8TL49
A0A8V8TL53
L8EAI3