POLR3D report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLR3D at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0042797Biological processtRNA transcription by RNA polymerase III
GO_0045089Biological processpositive regulation of innate immune response
GO_0045087Biological processinnate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePOLR3D
Protein nameRNA polymerase III subunit D
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)
SynonymsBN51T
BN51
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway . .

AccessionsENST00000518039.1
E5RHT4
P05423
ENST00000306433.9
E7EQ68
ENST00000397802.8
ENST00000519237.5