POLI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0019985Biological processtranslesion synthesis
GO_0006260Biological processDNA replication
GO_0042276Biological processerror-prone translesion synthesis
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePOLI
Protein nameDNA polymerase iota
DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)
SynonymsRAD30B
DescriptionFUNCTION: Error-prone DNA polymerase specifically involved in DNA repair . Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls . Favors Hoogsteen base-pairing in the active site . Inserts the correct base with high-fidelity opposite an adenosine template . Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine . May play a role in hypermutation of immunoglobulin genes . Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity . .

AccessionsX6R2I3
J3QQZ8
Q9UNA4
ENST00000579434.5
J3KRS8
ENST00000217800.9
ENST00000579534.6
J3QR36
ENST00000585023.5
ENST00000580880.1
J3KTN3
ENST00000581950.5
ENST00000579823.1
ENST00000406285.7
J3KRG0
J3KTM8
ENST00000583136.5
J3KQ09
J3KSW2
ENST00000577612.5