I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 22% ± 4% | |
| transit amplifying cell | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 3 studies | 22% ± 4% | |
| transit amplifying cell | 3 studies | 37% ± 15% |
Insufficient scRNA-seq data for expression of POLE at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3485.76 | 1445 / 1445 | 100% | 18.09 | 183 / 183 |
| uterus | 100% | 3377.03 | 170 / 170 | 100% | 18.11 | 457 / 459 |
| breast | 100% | 3322.92 | 459 / 459 | 99% | 12.40 | 1110 / 1118 |
| intestine | 100% | 3889.93 | 966 / 966 | 99% | 13.15 | 523 / 527 |
| bladder | 100% | 3521.19 | 21 / 21 | 99% | 12.62 | 499 / 504 |
| prostate | 100% | 4016.50 | 245 / 245 | 99% | 8.25 | 497 / 502 |
| skin | 100% | 4929.72 | 1808 / 1809 | 99% | 11.95 | 467 / 472 |
| stomach | 100% | 3350.53 | 359 / 359 | 98% | 13.65 | 281 / 286 |
| lung | 100% | 2741.80 | 576 / 578 | 96% | 10.85 | 1109 / 1155 |
| ovary | 100% | 3761.06 | 180 / 180 | 93% | 9.39 | 400 / 430 |
| pancreas | 98% | 1977.65 | 321 / 328 | 93% | 6.19 | 166 / 178 |
| liver | 100% | 2882.54 | 226 / 226 | 85% | 6.35 | 347 / 406 |
| thymus | 100% | 2562.45 | 652 / 653 | 76% | 5.69 | 457 / 605 |
| kidney | 97% | 1620.85 | 86 / 89 | 75% | 4.34 | 680 / 901 |
| brain | 67% | 3728.56 | 1763 / 2642 | 80% | 5.71 | 564 / 705 |
| adrenal gland | 98% | 1537.47 | 253 / 258 | 39% | 2.31 | 89 / 230 |
| adipose | 100% | 2822.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.06 | 29 / 29 |
| spleen | 100% | 9592.67 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 19.39 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.32 | 1 / 1 |
| blood vessel | 100% | 2934.15 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2518.89 | 795 / 803 | 0% | 0 | 0 / 0 |
| heart | 94% | 1513.75 | 809 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 86% | 5.56 | 69 / 80 |
| peripheral blood | 72% | 2535.53 | 666 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0048568 | Biological process | embryonic organ development |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0006287 | Biological process | base-excision repair, gap-filling |
| GO_0006260 | Biological process | DNA replication |
| GO_0045004 | Biological process | DNA replication proofreading |
| GO_0006272 | Biological process | leading strand elongation |
| GO_0000731 | Biological process | DNA synthesis involved in DNA repair |
| GO_0006297 | Biological process | nucleotide-excision repair, DNA gap filling |
| GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
| GO_0006261 | Biological process | DNA-templated DNA replication |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008622 | Cellular component | epsilon DNA polymerase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003887 | Molecular function | DNA-directed DNA polymerase activity |
| GO_0003677 | Molecular function | DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0008310 | Molecular function | single-stranded DNA 3'-5' DNA exonuclease activity |
| GO_0000166 | Molecular function | nucleotide binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| Gene name | POLE |
| Protein name | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) DNA polymerase epsilon catalytic subunit (EC 2.7.7.7) DNA polymerase epsilon, catalytic subunit |
| Synonyms | POLE1 |
| Description | FUNCTION: Catalytic component of the DNA polymerase epsilon complex . Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair . Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation . . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . FUNCTION: DNA polymerase II participates in chromosomal DNA replication. . |
| Accessions | F5H1D6 ENST00000699984.1 F5H7E4 ENST00000434528.5 A0A087WX51 ENST00000672742.1 ENST00000320574.10 A0A5F9ZHD6 Q07864 A0A087WW42 ENST00000441786.3 ENST00000544870.6 A0A5F9ZI42 A0A8V8TQW1 ENST00000672002.1 ENST00000539215.6 ENST00000699982.1 ENST00000699983.1 Q96IE1 ENST00000537064.5 ENST00000535270.5 A0A8V8TQH1 |
