POLA2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POLA2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLA2 at tissue level.

III. Associated gene sets

GO_0006270Biological processDNA replication initiation
GO_0006260Biological processDNA replication
GO_0006606Biological processprotein import into nucleus
GO_0006269Biological processDNA replication, synthesis of primer
GO_0005658Cellular componentalpha DNA polymerase:primase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene namePOLA2
Protein nameDNA polymerase alpha 2, accessory subunit
DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)
DNA polymerase alpha subunit B
Synonyms
DescriptionFUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis . During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). .

FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. .

AccessionsENST00000706536.1
ENST00000706534.1
H0YDR7
E9PIQ6
A0A9L9PX14
ENST00000706538.1
Q14181
ENST00000706540.1
ENST00000265465.8 [Q14181-1]
ENST00000527850.5
A0A9L9PY44
A0A9L9PXL3
ENST00000525924.2
ENST00000706535.1
ENST00000706537.1
ENST00000532391.1
E9PQ99