POFUT1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	27% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of POFUT1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	3522.98	180 / 180	100%	57.10	430 / 430
esophagus	100%	2717.78	1444 / 1445	100%	63.69	183 / 183
breast	100%	3342.69	459 / 459	100%	57.75	1117 / 1118
lung	100%	2744.13	578 / 578	100%	48.62	1153 / 1155
stomach	100%	2158.18	359 / 359	100%	85.61	285 / 286
intestine	100%	3387.21	966 / 966	100%	78.15	525 / 527
skin	100%	4454.90	1809 / 1809	100%	57.64	470 / 472
prostate	100%	2747.40	245 / 245	99%	39.41	499 / 502
kidney	100%	2648.93	89 / 89	99%	42.96	894 / 901
uterus	100%	3446.68	170 / 170	99%	44.71	454 / 459
thymus	100%	3441.08	653 / 653	99%	34.48	598 / 605
bladder	100%	3505.10	21 / 21	99%	50.23	497 / 504
pancreas	100%	1888.16	327 / 328	98%	34.61	175 / 178
brain	98%	1157.04	2591 / 2642	100%	43.89	704 / 705
liver	100%	3705.83	226 / 226	97%	38.63	395 / 406
adrenal gland	100%	2602.31	258 / 258	95%	26.96	218 / 230
adipose	100%	3278.24	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3532.10	1335 / 1335	0%	0	0 / 0
spleen	100%	1978.02	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.27	45 / 45
ureter	0%	0	0 / 0	100%	19.60	1 / 1
muscle	100%	1803.67	801 / 803	0%	0	0 / 0
heart	99%	2448.45	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	29.27	77 / 80
lymph node	0%	0	0 / 0	93%	19.30	27 / 29
peripheral blood	57%	1068.78	530 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0016266	Biological process	O-glycan processing
GO_0001525	Biological process	angiogenesis
GO_0008593	Biological process	regulation of Notch signaling pathway
GO_0001756	Biological process	somitogenesis
GO_0007219	Biological process	Notch signaling pathway
GO_0006004	Biological process	fucose metabolic process
GO_0006493	Biological process	protein O-linked glycosylation
GO_0007399	Biological process	nervous system development
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0007507	Biological process	heart development
GO_0036066	Biological process	protein O-linked fucosylation
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0046922	Molecular function	peptide-O-fucosyltransferase activity
GO_0008417	Molecular function	fucosyltransferase activity

Gene name	POFUT1
Protein name	GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) Protein O-fucosyltransferase 1 GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1)
Synonyms	KIAA0180 FUT12
Description	FUNCTION: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). .
Accessions	A0A9L9PY15 Q9H488 ENST00000706472.1 ENST00000375749.8 [Q9H488-1] ENST00000375730.3 [Q9H488-2] ENST00000706471.1 A0A9L9PX68

POFUT1 report