I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 7 studies | 21% ± 5% | |
| endothelial cell of artery | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 7 studies | 21% ± 5% | |
| endothelial cell of artery | 3 studies | 19% ± 3% |
Insufficient scRNA-seq data for expression of PNMT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 91% | 761.13 | 2400 / 2642 | 56% | 5.91 | 393 / 705 |
| bladder | 86% | 327.57 | 18 / 21 | 46% | 29.61 | 234 / 504 |
| breast | 73% | 335.26 | 334 / 459 | 47% | 32.53 | 523 / 1118 |
| adrenal gland | 52% | 3824.28 | 135 / 258 | 64% | 772.96 | 147 / 230 |
| prostate | 86% | 421.35 | 211 / 245 | 17% | 1.02 | 87 / 502 |
| uterus | 69% | 214.87 | 117 / 170 | 33% | 88.11 | 151 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.80 | 1 / 1 |
| muscle | 99% | 551.66 | 794 / 803 | 0% | 0 | 0 / 0 |
| thymus | 32% | 64.53 | 210 / 653 | 65% | 5.19 | 393 / 605 |
| heart | 94% | 534.46 | 807 / 861 | 0% | 0 | 0 / 0 |
| ovary | 46% | 119.21 | 83 / 180 | 47% | 6.77 | 204 / 430 |
| stomach | 75% | 252.00 | 271 / 359 | 11% | 1.10 | 32 / 286 |
| esophagus | 71% | 340.72 | 1024 / 1445 | 15% | 1.90 | 28 / 183 |
| lung | 66% | 448.62 | 382 / 578 | 18% | 1.55 | 212 / 1155 |
| intestine | 68% | 216.57 | 657 / 966 | 13% | 1.76 | 68 / 527 |
| blood vessel | 73% | 218.11 | 979 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 60% | 202.08 | 719 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 12% | 17.32 | 38 / 328 | 43% | 5.34 | 77 / 178 |
| kidney | 39% | 73.45 | 35 / 89 | 9% | 0.58 | 79 / 901 |
| spleen | 44% | 83.56 | 107 / 241 | 0% | 0 | 0 / 0 |
| skin | 31% | 83.56 | 556 / 1809 | 4% | 0.51 | 19 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.98 | 6 / 45 |
| liver | 0% | 0.80 | 1 / 226 | 10% | 1.16 | 39 / 406 |
| peripheral blood | 2% | 3.77 | 19 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042423 | Biological process | catecholamine biosynthetic process |
| GO_0032259 | Biological process | methylation |
| GO_0042418 | Biological process | epinephrine biosynthetic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0004603 | Molecular function | phenylethanolamine N-methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PNMT |
| Protein name | Phenylethanolamine N-methyltransferase Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (Noradrenaline N-methyltransferase) Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) |
| Synonyms | PENT |
| Description | FUNCTION: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor . Other substrates include phenylethanolamine and octopamine . Also methylates normetanephrine (By similarity). . |
| Accessions | ENST00000269582.3 Q6FHD9 A8MT87 ENST00000394246.1 ENST00000581428.1 P11086 J3QRI3 |
