PNLDC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PNLDC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PNLDC1 at tissue level.

III. Associated gene sets

GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0034587Biological processpiRNA processing
GO_1990432Biological processsiRNA 3'-end processing
GO_0007283Biological processspermatogenesis
GO_0001825Biological processblastocyst formation
GO_1990431Biological processpriRNA 3'-end processing
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePNLDC1
Protein namePARN like ribonuclease domain containing exonuclease 1
Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1)
Synonyms
DescriptionFUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails . Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development . May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs . .

AccessionsENST00000610273.5 [Q8NA58-1]
ENST00000610041.5
ENST00000392167.4 [Q8NA58-2]
ENST00000275275.9
V9GYA0
Q8NA58
ENST00000610048.5