Insufficient scRNA-seq data for expression of PLXNA3 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 7109.93 | 245 / 245 | 100% | 21.56 | 501 / 502 |
| ovary | 100% | 10310.49 | 180 / 180 | 100% | 31.06 | 428 / 430 |
| breast | 100% | 4044.23 | 459 / 459 | 99% | 23.57 | 1106 / 1118 |
| intestine | 100% | 4797.73 | 966 / 966 | 98% | 18.32 | 519 / 527 |
| thymus | 100% | 6982.25 | 653 / 653 | 98% | 19.53 | 595 / 605 |
| uterus | 100% | 6715.62 | 170 / 170 | 98% | 18.38 | 451 / 459 |
| esophagus | 99% | 3161.12 | 1427 / 1445 | 99% | 27.54 | 181 / 183 |
| pancreas | 99% | 2693.41 | 325 / 328 | 98% | 19.26 | 175 / 178 |
| bladder | 100% | 4697.62 | 21 / 21 | 97% | 19.14 | 490 / 504 |
| lung | 100% | 5460.66 | 576 / 578 | 97% | 18.92 | 1121 / 1155 |
| stomach | 99% | 2770.11 | 355 / 359 | 97% | 19.42 | 278 / 286 |
| adrenal gland | 100% | 4146.60 | 258 / 258 | 93% | 33.00 | 215 / 230 |
| brain | 92% | 4076.74 | 2438 / 2642 | 100% | 21.55 | 702 / 705 |
| kidney | 99% | 3285.48 | 88 / 89 | 92% | 11.68 | 826 / 901 |
| skin | 100% | 5385.13 | 1806 / 1809 | 84% | 11.49 | 397 / 472 |
| spleen | 100% | 4940.75 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.49 | 1 / 1 |
| adipose | 99% | 3946.24 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 6194.83 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 10.01 | 41 / 45 |
| heart | 90% | 2438.61 | 772 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 8.22 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 81% | 6.05 | 65 / 80 |
| liver | 35% | 595.20 | 78 / 226 | 39% | 4.29 | 157 / 406 |
| peripheral blood | 48% | 1254.64 | 443 / 929 | 0% | 0 | 0 / 0 |
| muscle | 19% | 262.98 | 152 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021628 | Biological process | olfactory nerve formation |
| GO_0021766 | Biological process | hippocampus development |
| GO_0050772 | Biological process | positive regulation of axonogenesis |
| GO_0021860 | Biological process | pyramidal neuron development |
| GO_0097485 | Biological process | neuron projection guidance |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0021612 | Biological process | facial nerve structural organization |
| GO_0048846 | Biological process | axon extension involved in axon guidance |
| GO_0021828 | Biological process | gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0021637 | Biological process | trigeminal nerve structural organization |
| GO_0021785 | Biological process | branchiomotor neuron axon guidance |
| GO_0043087 | Biological process | regulation of GTPase activity |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0051495 | Biological process | positive regulation of cytoskeleton organization |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_0007411 | Biological process | axon guidance |
| GO_0048843 | Biological process | negative regulation of axon extension involved in axon guidance |
| GO_0002116 | Cellular component | semaphorin receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0017154 | Molecular function | semaphorin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PLXNA3 |
| Protein name | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) Alternative protein PLXNA3 |
| Synonyms | PLXN4 SEX |
| Description | FUNCTION: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| Accessions | P51805 L8ECH0 ENST00000369682.4 |
