PLSCR4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLSCR4 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0005886Cellular componentplasma membrane
GO_0019899Molecular functionenzyme binding
GO_0042609Molecular functionCD4 receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding
GO_0017128Molecular functionphospholipid scramblase activity

IV. Literature review

[source]
Gene namePLSCR4
Protein namePhospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1)
Phospholipid scramblase
Phospholipid scramblase 4
SynonymsGIG43
DescriptionFUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

FUNCTION: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. .

AccessionsC9J664
E9PHR9
C9J3P9
ENST00000481701.5
ENST00000460350.5
C9JNW2
C9J916
ENST00000446574.6 [Q9NRQ2-1]
ENST00000493382.5 [Q9NRQ2-1]
ENST00000476202.5
ENST00000354952.7 [Q9NRQ2-1]
ENST00000433593.6 [Q9NRQ2-2]
Q9NRQ2
ENST00000498625.1
ENST00000460885.5
C9J6E1
ENST00000383083.6