PLPP6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLPP6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLPP6 at tissue level.

III. Associated gene sets

GO_0018342Biological processprotein prenylation
GO_1902565Biological processpositive regulation of neutrophil activation
GO_0045087Biological processinnate immune response
GO_0046839Biological processphospholipid dephosphorylation
GO_0006720Biological processisoprenoid metabolic process
GO_0045339Biological processfarnesyl diphosphate catabolic process
GO_0006695Biological processcholesterol biosynthetic process
GO_1902247Biological processgeranylgeranyl diphosphate catabolic process
GO_0033383Biological processgeranyl diphosphate metabolic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005637Cellular componentnuclear inner membrane
GO_0031965Cellular componentnuclear membrane
GO_0008195Molecular functionphosphatidate phosphatase activity
GO_0106405Molecular functionisoprenoid diphosphate phosphatase activity
GO_0016787Molecular functionhydrolase activity
GO_0052642Molecular functionlysophosphatidic acid phosphatase activity
GO_0042577Molecular functionlipid phosphatase activity
GO_0042392Molecular functionsphingosine-1-phosphate phosphatase activity
GO_0016829Molecular functionlyase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLPP6
Protein namePolyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase)
SynonymsPPAPDC2
PDP1
DescriptionFUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates . Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation . May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway . May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins . Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols . May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate . .

AccessionsQ8IY26
ENST00000381883.5